Scientists tie walnluts to gene expressions related to Breast Cancer


by Marshall University Joan C. Edwards School of Medicine

Scientists at Marshall University have tied walnuts to gene expressions related to breast cancer. Credit: Marshall University Joan C. Edwards School of Medicine

New research from Marshall University links walnut consumption as a contributing factor that could suppress growth and survival of breast cancers.

Led by W. Elaine Hardman, Ph.D., a professor in the Department of Biomedical Sciences at the Marshall University Joan C. Edwards School of Medicine, a Marshall University team revealed that consumption of two ounces of walnuts a day for about two weeks significantly changed gene expression in confirmed breast cancers. This pilot, two-arm clinical trial is the latest of a series of related studies at Marshall University related to dietary walnut links to tumor growth, survival and metastasis in breast cancer. The work is described in a March 10 paper published in the journal Nutrition Research.

"Consumption of walnuts has slowed breast cancer growth and/or reduced the risk of mammary cancer in mice," Hardman said. "Building on this research, our team hypothesized that walnut consumption would alter gene expression in pathologically-confirmed breast cancers of women in a direction that would decrease breast cancer growth and survival."

In this first clinical trial, women with breast lumps large enough for research and pathology biopsies were recruited and randomized to walnut consuming or control groups. Immediately following biopsy collection, women in the walnut group began to consume two ounces of walnuts per day until follow-up surgery. Pathological studies confirmed that lumps were breast cancer in all women who remained in the trial. At surgery, about two weeks after biopsy, additional specimens were taken from the breast cancers.

Changes in gene expression in the surgical specimen compared to baseline were determined in each individual woman in walnut-consuming (n = 5) and control (n = 5) groups. RNA sequencing expression profiling revealed that expression of 456 identified genes was significantly changed in the tumor due to walnut consumption. Ingenuity Pathway Analysis showed activation of pathways that promote apoptosis and cell adhesion and inhibition of pathways that promote cell proliferation and migration.

"These results support the hypothesis that, in humans, walnut consumption could suppress growth and survival of breast cancers," Hardman said. "Additional research through a larger-scale study would be needed to clinically confirm that walnut consumption actually does reduce the risk of breast cancer or breast cancer recurrence."

This study is an example of the critical role of a team in modern research. Breast surgeons Mary Legenza, M.D., of Marshall University Joan C. Edwards School of Medicine and Edwards Comprehensive Cancer Center, and James Morgan, M.D., formerly of St. Mary's Medical Center, collected biopsies from patient volunteers for the clinical trial. Donald A. Primerano, Ph.D., Jun Fan, Ph.D., and James Denvir, Ph.D., of the Genomics and Bioinformatics Core Facility at Marshall University Joan C. Edwards School of Medicine performed the RNA expression profiling, bioinformatic and statistical analyses.

Walnuts shown to activate brain region involved in appetite control

Controlled portions of nuts such as walnuts are often recommended for patients with obesity and type-2 diabetes because they are thought to discourage overeating by promoting feelings of fullness. How the nuts might do so, however, remains murky.

In a small new brain-imaging study partially sponsored by the California Walnut Commission, researchers at Harvard Medical School and Beth Israel Deaconess Medical Center have found that consuming walnuts activates an area in the brain associated with regulating hunger and cravings.


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